Chromosomal localization of gene for human glutamate receptor subunit-7

Somat Cell Mol Genet. 1993 Nov;19(6):581-8. doi: 10.1007/BF01233385.


We isolated a human glutamate receptor subunit 7 (GluR-7) cosmid after high stringency screening of a human genomic placental library using a rat GluR-7 cDNA as a probe. A 614-bp fragment of the GluR-7 cosmid was sequenced, and an exon that encodes 53 amino acids was found between two introns. The exon exhibited 89% and 96% identity at the nucleotide and amino acid levels, respectively, with the corresponding region of rat GluR-7. The human GluR-7 was classified as a kainate subtype glutamate receptor based on its homology to rat GluR-7. Using somatic cell hybrid analysis, human GluR-7 was localized to chromosome 1. Fine mapping analysis using FISH localized the gene to 1p33-34. Since glutamate receptors of the kainate subtype have been implicated in neurodegenerative disorders, establishing the precise map position of human GluR-7 subunit is an important step towards evaluating this locus as a candidate for mutations in neurodegenerative disorders.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Southern
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Cosmids
  • Humans
  • Hybrid Cells
  • In Situ Hybridization, Fluorescence
  • Molecular Sequence Data
  • Rats
  • Receptors, Kainic Acid / chemistry
  • Receptors, Kainic Acid / genetics*
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid


  • Receptors, Kainic Acid