A parent-twin study of plasma levels of histidine-rich glycoprotein (HRG)

Thromb Haemost. 1993 Nov 15;70(5):848-51.


Histidine-rich glycoprotein (HRG) is a non-enzymatic glycoprotein that acts as a modulator of several plasma proteins involved in coagulation and fibrinolysis. The contributions of genetic and environmental influences to inter-individual variation in plasma levels of HRG were studied in 160 Dutch families consisting of adolescent twin pairs and their parents. Results showed that 69% of the variance in plasma HRG concentrations could be accounted for by genetic factors. Heritability was the same in males and females and in parents and their offspring. There was no association between HRG levels of husband and wife and no evidence was found for the influence of shared family environment on the resemblance between relatives.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Environment
  • Female
  • Genotype
  • Humans
  • Likelihood Functions
  • Male
  • Middle Aged
  • Parents*
  • Proteins / analysis*
  • Proteins / genetics
  • Sex Factors
  • Twins*
  • Twins, Dizygotic
  • Twins, Monozygotic


  • Proteins
  • histidine-rich proteins