Biochemical pathology and treatment strategies in Alzheimer's disease: emphasis on the cholinergic system

Acta Neurol Scand Suppl. 1993;149:4-6. doi: 10.1111/j.1600-0404.1993.tb04244.x.

Abstract

The neurochemical pathology of Alzheimer's disease (AD) has been consistently shown to involve cholinergic degeneration in the cerebral cortex. This together with evidence from experimental animal studies showing that cholinergic neurones play a role in learning and memory processes has formed the basis of the cholinergic hypothesis of Alzheimer's dementia and the major rationale for neurotransmitter replacement therapy of the disorder.

MeSH terms

  • Acetylcholine / metabolism
  • Acetylcholine / physiology
  • Aged
  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / physiopathology*
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Cerebral Cortex / physiopathology
  • Cholinesterase Inhibitors / pharmacology
  • Cholinesterase Inhibitors / therapeutic use
  • Female
  • Humans
  • Male
  • Parasympathetic Nervous System / physiopathology*
  • Parasympathomimetics / pharmacology
  • Parasympathomimetics / therapeutic use*
  • Phosphatidylcholines / pharmacology
  • Phosphatidylcholines / therapeutic use

Substances

  • Cholinesterase Inhibitors
  • Parasympathomimetics
  • Phosphatidylcholines
  • Acetylcholine