4-aminopyridine in the treatment of patients with multiple sclerosis. Long-term efficacy and safety

Arch Neurol. 1994 Mar;51(3):292-6. doi: 10.1001/archneur.1994.00540150090022.


Objective: To study the long-term efficacy and safety of 4-aminopyridine in patients with multiple sclerosis.

Design: Case series, follow-up varying from 6 to 32 months.

Setting: University referral center.

Patients: Thirty-one patients with definite MS, 23 of them being exposed to long-term administration (6 to 32 months) of 4-aminopyridine, since they showed a favorable initial response to the drug.

Interventions: Long-term oral treatment with 4-aminopyridine in daily doses of up to 0.5 mg/kg of body weight.

Main outcome measures: Neurologic functions and symptoms as reported by the patients; side effects.

Results: Twenty of 23 patients who showed a favorable initial response benefited from long-term administration. Ambulation and fatigue (each in 13 patients) and visual function (in five patients) were most frequently reported to be improved. Three major side effects did occur during a follow-up of 406 patient months: a generalized epileptic seizure in two patients and hepatitis in one.

Conclusions: Although a substantial proportion of patients with multiple sclerosis seem to benefit from long-term administration of 4-aminopyridine, additional studies are needed to clarify the exact value of the drug.

MeSH terms

  • 4-Aminopyridine / adverse effects
  • 4-Aminopyridine / therapeutic use*
  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / drug therapy*


  • 4-Aminopyridine