Differential effects of protein kinase inhibitors and activators on memory formation in the 2-day-old chick

Behav Neural Biol. 1994 Jan;61(1):60-72. doi: 10.1016/s0163-1047(05)80045-7.

Abstract

Thirteen protein kinase inhibitors (PKIs) were investigated in chicks for their in vitro effects on PKC activity and for their in vivo effects on memory formation for a peak-avoidance task. Amnesia occurred by 15-30 min post-training when agents that inhibit primarily Ca2+/calmodulin were injected into brain. Amnesia occurred by 60 min post-training when agents that inhibit PKC-, PKA-, and/or PKG-dependent protein kinases, but not Ca2+/calmodulin, were injected. Enhancement of memory formation was accomplished by injecting bradykinin, but not forskolin. Both of these agents, however, attenuated the amnesia produced by H-7. These results are discussed as relevant neural processes involved in memory and synaptic plasticity.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amnesia / chemically induced
  • Animals
  • Animals, Newborn / physiology*
  • Avoidance Learning / drug effects
  • Avoidance Learning / physiology
  • Bradykinin / pharmacology
  • Brain / drug effects
  • Brain Chemistry
  • Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors*
  • Calcium-Calmodulin-Dependent Protein Kinases / physiology*
  • Chickens / physiology*
  • Colforsin / pharmacology
  • Memory / drug effects
  • Memory / physiology*
  • Phosphorylation
  • Protein Kinase C / antagonists & inhibitors*
  • Protein Kinase C / physiology*

Substances

  • Colforsin
  • Protein Kinase C
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Bradykinin