The regulation of sex determination and sexually dimorphic differentiation in Drosophila

Curr Opin Cell Biol. 1993 Dec;5(6):1006-14. doi: 10.1016/0955-0674(93)90085-5.


Sex determination and sexually dimorphic differentiation in Drosophila involve multiple regulatory mechanisms, including alternative splicing, transcriptional control, subcellular compartmentalization, and intercellular signal transduction. Regulatory interactions occur throughout the development of the fly, some requiring the continuous function of the genes involved, and others being temporally limited, but having permanent consequences. The control of sexual differentiation in Drosophila is, for the most part, subject to the continuous active control of numerous regulatory proteins operating at many levels.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Drosophila / embryology
  • Drosophila / genetics*
  • Female
  • Gene Expression Regulation
  • Genes, Insect*
  • Male
  • Organ Specificity
  • Sex Characteristics*
  • Sex Determination Analysis*