The diagnosis of osteomyelitis in the presence of soft tissue infection and neuropathic bone changes is often difficult in the diabetic foot. Previous attempts at scintigraphic diagnosis included Tc-99m methylene diphosphonate, Gallium-67 citrate and Indium-111 autologous leukocytes (WBCs). A new agent recently available, Technetium-99m-HMPAO labeled white blood cells, shows promise as a scintigraphic agent superior to other agents for this purpose. The authors discuss this agent and present a case report as a preliminary study.