Clinical and Epidemiologic Investigations of Nosocomial Pulmonary Infections Caused by Methicillin-Resistant Staphylococcus Aureus

Chest. 1994 Mar;105(3):826-31. doi: 10.1378/chest.105.3.826.


We evaluated the clinical features of 32 patients with pulmonary infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Most of the patients were elderly, postoperative, and had severe underlying diseases. Chest radiograph typically showed bilateral and multilobar involvement. Empyema was not common and no abscess was identified. Mortality rate was 38 percent. We also performed an epidemiologic study of MRSA infections by chromosomal DNA analysis using pulsed-field gel electrophoresis. Thirty-two strains were classified into 20 different types by chromosomal DNA pattern, and 5 epidemic strains were observed. These strains were considered to be transmitted among patients by hospital personnel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cross Infection / epidemiology*
  • Cross Infection / microbiology*
  • Cross Infection / transmission
  • DNA, Bacterial / analysis
  • Disease Outbreaks*
  • Electrophoresis, Gel, Pulsed-Field
  • Female
  • Humans
  • Infectious Disease Transmission, Professional-to-Patient
  • Japan / epidemiology
  • Male
  • Methicillin Resistance / genetics*
  • Microbial Sensitivity Tests
  • Middle Aged
  • Pneumonia, Staphylococcal / epidemiology*
  • Pneumonia, Staphylococcal / microbiology
  • Pneumonia, Staphylococcal / transmission
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / isolation & purification*


  • DNA, Bacterial