The treatment of sleep disorders with melatonin

Dev Med Child Neurol. 1994 Feb;36(2):97-107. doi: 10.1111/j.1469-8749.1994.tb11818.x.


Fifteen children (most of whom were neurologically multiply disabled) with severe, chronic sleep disorders were treated with 2 to 10mg of oral melatonin, given at bedtime. Nine had fragmented sleep patterns, three had delayed sleep onset and three others had non-specific sleep disturbance of unclear aetiology; all had failed to respond to conventional management. Nine patients had ocular or cortical visual impairment. The health, behavioural and social benefits of treatment were significant, and there were no adverse side-effects. While the response was not always complete, the study clearly showed that melatonin has an important role in the treatment of certain types of chronic sleep disorders.

Publication types

  • Case Reports
  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Blindness / complications
  • Child
  • Child, Preschool
  • Chronic Disease
  • Circadian Rhythm / physiology
  • Disabled Persons
  • Double-Blind Method
  • Female
  • Humans
  • Infant
  • Male
  • Melatonin / therapeutic use*
  • Sleep Wake Disorders / complications
  • Sleep Wake Disorders / drug therapy*
  • Sleep Wake Disorders / physiopathology


  • Melatonin