Increasing incidence of adenovirus disease in bone marrow transplant recipients

J Infect Dis. 1994 Apr;169(4):775-81. doi: 10.1093/infdis/169.4.775.


Adenovirus infections in 201 bone marrow transplant (BMT) recipients over 4 years were retrospectively reviewed. Forty-two patients (20.9%) had positive adenovirus cultures after BMT. There was a higher incidence of adenovirus infections in pediatric patients than in adults (31.3% vs. 13.6%, P = .003). In addition, the time of onset of adenovirus infection after transplant was earlier in pediatric patients (mean, < 30 days) than in adults (> 90 days). Adenovirus type 35 was the most common serotype identified. One-third of adenovirus-positive patients had definite or probable adenovirus disease. Moderate to severe acute graft-versus-host disease and isolation of adenovirus from two or more sites were significant risk factors for adenovirus disease. This report documents a higher incidence of both adenovirus infection and disease than do previous studies. Adenovirus may emerge as a more frequent pathogen as more high-risk BMT transplants are done.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenovirus Infections, Human / epidemiology*
  • Adenovirus Infections, Human / etiology
  • Adenoviruses, Human / classification
  • Adenoviruses, Human / isolation & purification
  • Adolescent
  • Adult
  • Age Factors
  • Anemia, Aplastic / surgery
  • Bone Marrow Transplantation*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Female
  • Graft vs Host Disease / complications
  • Humans
  • Incidence
  • Infant
  • Leukemia / surgery
  • Lymphoma / surgery
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / surgery
  • Retrospective Studies
  • Risk Factors
  • Serotyping
  • Time Factors