SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins

Oncogene. 1994 Apr;9(4):1205-11.


Amplification of 12q13-14 occurs in a subset of human sarcomas including malignant fibrous histiocytoma and liposarcoma. This chromosomal region has previously been found to include a number of growth-related genes including the GLI proto-oncogene and the p53-associated protein, MDM2. We now report the characterization of SAS (sarcoma amplified sequence), a novel transcript found in this region. Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes. This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Northern
  • Cells, Cultured
  • Chromosomes, Human, Pair 12
  • Consensus Sequence
  • Gene Amplification*
  • Humans
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics*
  • Proto-Oncogene Mas
  • Restriction Mapping
  • Sarcoma / genetics*
  • Sequence Homology, Amino Acid
  • Tetraspanins


  • MAS1 protein, human
  • Membrane Proteins
  • Neoplasm Proteins
  • Proto-Oncogene Mas
  • TSPAN31 protein, human
  • Tetraspanins

Associated data

  • GENBANK/U01160