In vitro inhibition of cyclooxygenase and 5-lipoxygenase by alkamides from Echinacea and Achillea species

Planta Med. 1994 Feb;60(1):37-40. doi: 10.1055/s-2006-959404.


Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenase (porcine leukocytes) assays. Activity appeared to depend on the particular structure of the alkamides.

MeSH terms

  • Amides / pharmacology*
  • Animals
  • Cyclooxygenase Inhibitors / isolation & purification
  • Cyclooxygenase Inhibitors / pharmacology*
  • Lipoxygenase Inhibitors*
  • Plants, Medicinal / chemistry*
  • Sheep
  • Swine


  • Amides
  • Cyclooxygenase Inhibitors
  • Lipoxygenase Inhibitors