Occult intracranial aneurysms in polycystic kidney disease: screening with MR angiography

Radiology. 1994 Apr;191(1):33-9. doi: 10.1148/radiology.191.1.8134594.


Purpose: To estimate the prevalence, location, and type of cerebral aneurysms in patients with adult polycystic kidney disease (PCKD) and identify associated risk factors.

Materials and methods: Ninety-three patients with PCKD were screened for aneurysms with spin-echo parenchymal magnetic resonance (MR) imaging and three-dimensional time-of-flight MR angiography. Prevalence was estimated with the calculated proportions of patients who had aneurysms, adjusted for reported sensitivity and specificity of MR angiography.

Results: Thirteen aneurysms, found in 10 patients, were 7 mm or smaller in largest dimension; 11 of these aneurysms were saccular. Intra- and interobserver variabilities were 96%-98%. Conventional arteriograms, obtained in six patients, helped confirm the MR angiographic findings. The best estimates of prevalence of aneurysms were 11.7% in the study group (n = 93) and 25.8% in patients with a family history of aneurysms (n = 6).

Conclusion: The prevalence of aneurysms in the study group was greater than in the general population. MR angiography is useful in screening for cerebral aneurysms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Cerebral Arteries / pathology
  • Female
  • Humans
  • Intracranial Aneurysm / complications
  • Intracranial Aneurysm / diagnosis*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Observer Variation
  • Polycystic Kidney Diseases / complications*
  • Prospective Studies
  • Risk Factors
  • Sensitivity and Specificity