Cerebral Blood Volume Maps of Gliomas: Comparison With Tumor Grade and Histologic Findings

Radiology. 1994 Apr;191(1):41-51. doi: 10.1148/radiology.191.1.8134596.

Abstract

Purpose: To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas.

Materials and methods: CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material.

Results: The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity.

Conclusion: MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Astrocytoma / diagnosis*
  • Astrocytoma / pathology
  • Astrocytoma / physiopathology
  • Blood Volume*
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / physiopathology
  • Cerebrovascular Circulation
  • Echo-Planar Imaging
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged