Limited Cleavage of Human Immunoglobulins by Elastase of Human Neutrophil Polymorphonuclear Granulocytes. Possible Modulator of Immune Complex Disease

Lab Invest. 1978 Oct;39(4):313-21.

Abstract

Human polymorphonuclear lysosomal granules contain a neutral protease which is capable of digesting human immunoglobulins. The protease is located in the azurophil granules and enzymatically cleaves IgG, producing a Fab-like piece which is recoverable. The Fc-like fragment is not crystallized. The Fab-like fragment competes effectively for ligands formed by native antibody from which the fragments were produced.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Epitopes
  • Humans
  • Immune Complex Diseases / immunology*
  • Immunoglobulin Fab Fragments / immunology
  • Immunoglobulin Fragments / immunology*
  • Immunoglobulin G / metabolism*
  • Neutrophils / enzymology*
  • Pancreatic Elastase / isolation & purification
  • Pancreatic Elastase / metabolism*
  • alpha 1-Antitrypsin / pharmacology

Substances

  • Epitopes
  • Immunoglobulin Fab Fragments
  • Immunoglobulin Fragments
  • Immunoglobulin G
  • alpha 1-Antitrypsin
  • Pancreatic Elastase