Abstract
Human polymorphonuclear lysosomal granules contain a neutral protease which is capable of digesting human immunoglobulins. The protease is located in the azurophil granules and enzymatically cleaves IgG, producing a Fab-like piece which is recoverable. The Fc-like fragment is not crystallized. The Fab-like fragment competes effectively for ligands formed by native antibody from which the fragments were produced.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Epitopes
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Humans
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Immune Complex Diseases / immunology*
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Immunoglobulin Fab Fragments / immunology
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Immunoglobulin Fragments / immunology*
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Immunoglobulin G / metabolism*
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Neutrophils / enzymology*
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Pancreatic Elastase / isolation & purification
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Pancreatic Elastase / metabolism*
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alpha 1-Antitrypsin / pharmacology
Substances
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Epitopes
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Immunoglobulin Fab Fragments
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Immunoglobulin Fragments
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Immunoglobulin G
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alpha 1-Antitrypsin
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Pancreatic Elastase