Rat heart fatty acid-binding protein content is increased in experimental diabetes

Biochem Biophys Res Commun. 1994 Mar 15;199(2):639-46. doi: 10.1006/bbrc.1994.1276.

Abstract

Cytoplasmic fatty acid-binding protein (FABP) was assayed immunochemically in hearts from rats with insulin-dependent (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM). FABP contents were 34% higher in IDDM and 103% higher in NIDDM hearts than in respective age-matched controls. FABP levels returned to control values when islets of Langerhans were transplanted into diabetic IDDM animals. In the diabetic hearts the activity of fructose-6-phosphate kinase decreased (IDDM and NIDDM animals), while that of 3-hydroxyacyl-CoA dehydrogenase increased (NIDDM animals only). These data indicate that experimental diabetes induces a marked increase of the FABP content of rat heart and suggests that this protein is involved in the enhanced fatty acid utilization by the diabetic heart.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Carrier Proteins / metabolism*
  • Cytosol / metabolism
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / metabolism*
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / metabolism*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / metabolism*
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Fatty Acids / metabolism
  • Female
  • Glucose Tolerance Test
  • Glycosuria
  • Insulin / blood
  • Lipids / blood
  • Male
  • Myocardium / metabolism*
  • Neoplasm Proteins*
  • Nerve Tissue Proteins*
  • Rats
  • Rats, Inbred BN
  • Rats, Inbred WF
  • Reference Values

Substances

  • Blood Glucose
  • Carrier Proteins
  • Fabp7 protein, rat
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Fatty Acids
  • Insulin
  • Lipids
  • Neoplasm Proteins
  • Nerve Tissue Proteins