Indirect presentation of MHC antigens in transplantation

Immunol Today. 1994 Jan;15(1):32-8. doi: 10.1016/0167-5699(94)90023-X.

Abstract

T cells can recognise foreign major histocompatibility complex (MHC) antigens by two distinct routes, either directly as intact molecules or indirectly as peptides after antigen processing. Danny Shoskes and Kathryn Wood review the evidence that indirect presentation of allopeptides may play a significant role in the events leading to the rejection or acceptance of allo- and xenografts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / physiology*
  • Histocompatibility Antigens Class I / physiology
  • Histocompatibility Antigens Class II / physiology
  • Humans
  • Major Histocompatibility Complex / immunology*
  • Transplantation Immunology / physiology*

Substances

  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II