On the mechanism of action of quinolone drugs

Trends Microbiol. 1993 Sep;1(6):232-5. doi: 10.1016/0966-842x(93)90138-h.


Antibacterial quinolones are thought to inhibit DNA gyrase by trapping the enzyme as a complex with the DNA substrate. The precise molecular details of drug-DNA and drug-enzyme interactions remain controversial. Here, a model is proposed that accounts for the influence of magnesium ions on quinolone-DNA binding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Quinolones
  • Anti-Infective Agents / metabolism*
  • Bacteria / enzymology*
  • DNA Topoisomerases, Type II / genetics
  • DNA Topoisomerases, Type II / metabolism*
  • Drug Resistance, Microbial / genetics
  • Magnesium / physiology
  • Models, Biological


  • 4-Quinolones
  • Anti-Infective Agents
  • DNA Topoisomerases, Type II
  • Magnesium