Effect of phencyclidine on dopamine release in the rat prefrontal cortex; an in vivo microdialysis study

Brain Res. 1994 Jan 7;633(1-2):337-42. doi: 10.1016/0006-8993(94)91558-x.

Abstract

The effect of phencyclidine (PCP) on the extracellular dopamine levels in the rat prefrontal cortex was investigated using an in vivo brain dialysis technique. PCP increased extracellular dopamine levels in the prefrontal cortex of freely-moving rats after the systemic (7.5 mg/kg i.p.) or the local injection (100 microM and 500 microM). The local injection of MK-801, which is a more selective and potent NMDA receptor antagonist than PCP also increased the extracellular dopamine levels (from 10 microM to 100 microM). These results suggest that part of the effect of PCP is attributable to its antagonist effect on the NMDA receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Chromatography, High Pressure Liquid
  • Dizocilpine Maleate / pharmacology
  • Dopamine / metabolism*
  • Extracellular Space / drug effects
  • Extracellular Space / metabolism
  • Male
  • Microdialysis
  • Phencyclidine / pharmacology*
  • Prefrontal Cortex / drug effects
  • Prefrontal Cortex / metabolism*
  • Rats
  • Rats, Wistar
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Tetrodotoxin / pharmacology

Substances

  • Receptors, N-Methyl-D-Aspartate
  • 3,4-Dihydroxyphenylacetic Acid
  • Tetrodotoxin
  • Dizocilpine Maleate
  • Phencyclidine
  • Dopamine