Focal glomerular sclerosis and nephrotic syndrome in spondyloepiphyseal dysplasia

Nephron. 1994;66(2):219-24. doi: 10.1159/000187804.


The association of a spondyloepiphyseal dysplasia and disproportionate short stature with focal glomerular sclerosis is reported in two girls. Renal disease manifested by proteinuria at the age of 2.5 and 11 years, leading to treatment-resistant nephrotic syndrome over 15 and 45 months, respectively. One patient went into end-stage renal failure shortly after nephrotic syndrome developed, the other died from sepsis. The association of spondyloepiphyseal dysplasia and focal glomerular sclerosis with nephrotic syndrome may represent a distinct disease entity.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Child, Preschool
  • Female
  • Glomerulosclerosis, Focal Segmental / complications*
  • Humans
  • Nephrotic Syndrome / complications*
  • Osteochondrodysplasias / complications*