Vigabatrin as an anticonvulsant against pentylenetetrazol seizures

Pharmacol Res. 1993 Dec;28(4):325-31. doi: 10.1006/phrs.1993.1134.


The anticonvulsant effects of gamma vinyl GABA (GVG) were investigated against pentylenetetrazol (PTZ) seizures, while sodium valproate (VP) was used as positive control. At 1000 and 1500 mg kg-1 GVG was found to decrease seizure intensity either in 4 or 24 h, as effectively as VP. At 2000 mg kg-1 GVG was found to be almost ineffective. At both doses and both time spans of drug action, seizure latency was prolonged, compared to controls and VP group.

MeSH terms

  • Aminocaproates / therapeutic use*
  • Animals
  • Anticonvulsants / therapeutic use*
  • Dose-Response Relationship, Drug
  • Female
  • Mice
  • Mice, Inbred BALB C
  • Pentylenetetrazole
  • Seizures / prevention & control*
  • Vigabatrin
  • gamma-Aminobutyric Acid / cerebrospinal fluid


  • Aminocaproates
  • Anticonvulsants
  • gamma-Aminobutyric Acid
  • Vigabatrin
  • Pentylenetetrazole