We have presented a case of symptomatic macular fluorescence of a presumed vascular etiology that transiently disappeared post vitrectomy. Laser photocoagulation to the involved area resulted in a good visual outcome. We propose that the transient improvement in the fluorescein leakage represented a temporary alteration of cellular metabolism, or vascular perfusion, attributable to the perfusion solution. We suggest that additional studies are indicated to further explore this phenomenon and its potential clinical applicability.