The secretion pathway of IgA protease-type proteins in gram-negative bacteria

Bioessays. 1993 Dec;15(12):799-805. doi: 10.1002/bies.950151205.


The pathogenic, Gram-negative bacteria, Neisseria gonorrhoeae, Neisseria meningitidis and Haemophilus influenzae, secrete immunoglobulin A1 proteases into their extracellular surroundings. An extraordinary feature in the secretory pathway of these putative virulence factors is a self-directed outer membrane transport step allowing the proteins to be secreted autonomously, even from foreign Gram-negative host cells like Escherichia coli. Here we summarize recent achievements in the understanding of IgA protease outer membrane translocation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Outer Membrane Proteins / metabolism
  • Bacterial Proteins / physiology*
  • Biological Transport
  • Genes, Bacterial
  • Gram-Negative Bacteria / genetics
  • Gram-Negative Bacteria / pathogenicity
  • Gram-Negative Bacteria / physiology*
  • Molecular Sequence Data
  • Peptide Hydrolases / metabolism*
  • Protein Processing, Post-Translational
  • Recombinant Fusion Proteins / metabolism
  • Serine Endopeptidases*
  • Virulence


  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Recombinant Fusion Proteins
  • Peptide Hydrolases
  • Serine Endopeptidases
  • IgA-specific serine endopeptidase