[The central vascular and metabolic effects of pyroglutamic acid]

Eksp Klin Farmakol. 1994 Jan-Feb;57(1):22-4.
[Article in Russian]

Abstract

The ability of pyroglutamic acid, a cyclic glutamic acid derivative, to increase cerebral blood flow, to decrease the resistance of brain vessels, and to relax the isolated grafts of cerebral arteries has been demonstrated. Pyroglutamic acid markedly stimulated brain metabolism: increased glucose uptake and utilization by cerebral tissues and decreased brain lactate dehydrogenase activity.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Carbon Radioisotopes
  • Cats
  • Cerebral Arteries / drug effects*
  • Cerebral Arteries / metabolism*
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Dogs
  • Glucose / metabolism
  • In Vitro Techniques
  • L-Lactate Dehydrogenase / drug effects
  • L-Lactate Dehydrogenase / metabolism
  • Pyrrolidonecarboxylic Acid / pharmacology*
  • Rats
  • Serotonin / pharmacology
  • Time Factors
  • Vascular Resistance / drug effects

Substances

  • Carbon Radioisotopes
  • Serotonin
  • L-Lactate Dehydrogenase
  • Glucose
  • Pyrrolidonecarboxylic Acid