Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23)

Receptor. 1993 Winter;3(4):325-41.

Abstract

Models of the lectin-homology domains of the human and murine low-affinity receptors for IgE (Fc epsilon RII/CD23) were built on the basis of sequence similarity with rat mannose-binding protein, the structure of which is known. The sites on Fc epsilon RII/CD23 that are possibly involved in the interaction with IgE and with another ligand, CD21/CR2, are proposed. The models may assist the design of protein engineering experiments for the study of the reactivity of these molecules.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Carrier Proteins / chemistry
  • Computer Simulation
  • Humans
  • Lectins / chemistry*
  • Mannose-Binding Lectins
  • Mice
  • Models, Molecular
  • Molecular Sequence Data
  • Rats
  • Receptors, Fc / chemistry*
  • Receptors, IgE / chemistry*
  • Sequence Homology, Amino Acid*
  • Structure-Activity Relationship

Substances

  • Carrier Proteins
  • Lectins
  • Mannose-Binding Lectins
  • Receptors, Fc
  • Receptors, IgE