Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control

Y Zhang; D B Young

doi:10.1016/0966-842x(93)90117-a

Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control

Trends Microbiol. 1993 Jun;1(3):109-13. doi: 10.1016/0966-842x(93)90117-a.

Authors

Y Zhang¹, D B Young

Affiliation

¹ MRC Tuberculosis and Related Infections Unit, RPMS, Hammersmith Hospital, London, UK.

PMID: 8143118
DOI: 10.1016/0966-842x(93)90117-a

Abstract

The resurgence of tuberculosis and emergence of multidrug-resistant isolates has focused attention on the need for an improved understanding of molecular aspects of the disease, and for elucidation of the factors responsible for drug action and resistance. Recent research has probed the mechanism of action of isoniazid (INH), a key drug in the chemotherapy of tuberculosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacterial Proteins*
Drug Resistance, Microbial / genetics
Humans
Isoniazid / pharmacology*
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / enzymology
Mycobacterium tuberculosis / genetics
Mycobacterium tuberculosis / pathogenicity
Peroxidases / genetics
Peroxidases / physiology
Virulence

Substances

Bacterial Proteins
Peroxidases
catalase HPI
Isoniazid