Novel targets and catalytic activities of bacterial protein toxins

Trends Microbiol. 1993 Aug;1(5):170-4. doi: 10.1016/0966-842x(93)90086-7.


Among bacterial protein toxins with intracellular targets, tetanus and botulinum toxins form a group with unique properties. They are absolutely neurospecific and act in the cytosol of neurons. Recent evidence indicates that they are zinc proteases specific for proteins of the neuroexocytosis apparatus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / pharmacology*
  • Bacterial Toxins / pharmacology*
  • Botulinum Toxins / pharmacology*
  • Membrane Proteins / metabolism
  • Molecular Sequence Data
  • Nerve Tissue Proteins / metabolism
  • Neurotoxins / pharmacology*
  • R-SNARE Proteins


  • Bacterial Proteins
  • Bacterial Toxins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Neurotoxins
  • R-SNARE Proteins
  • Botulinum Toxins