Inversion (14)(q11q32) in childhood T-cell acute lymphoblastic leukemia

Cancer Genet Cytogenet. 1994 Feb;72(2):92-5. doi: 10.1016/0165-4608(94)90121-x.


Inversion (14)(q11q32) is a common cytogenetic aberration in T-cell chronic lymphoid malignancies but is rare in T-cell acute lymphoblastic leukemia (T-ALL). We describe two cases of childhood T-ALL in which inv(14)(q11q32) was present concomitantly with other karyotypic aberrations typical of T-ALL. The possible significance of inv(14) in these cases is also discussed.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Child, Preschool
  • Chromosome Inversion*
  • Chromosomes, Human, Pair 14*
  • Female
  • Humans
  • Immunophenotyping
  • Leukemia-Lymphoma, Adult T-Cell / genetics*
  • Leukemia-Lymphoma, Adult T-Cell / immunology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology