After proper classification of cutaneous lesions in LE patients and extensive evaluation, we can begin to approach effective therapy. Patients with CLE (DLE or SCLE) generally have a favorable prognosis and can be managed with safe yet effective therapy. Sunscreens are the most important topical therapy. Intralesional corticosteroids are an effective local adjunctive therapy, useful in bringing lesions under control. Systemic therapy with antimalarials, either used singly or in combination, is usually effective. When "standard" therapy fails, azathioprine, retinoids, or occasionally dapsone may be effective.