HIV-inhibitory natural products. 11. Comparative studies of sulfated sterols from marine invertebrates

J Med Chem. 1994 Mar 18;37(6):793-7. doi: 10.1021/jm00032a012.

Abstract

A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values of 3-13 microM against HIV-1 (RF) and 2-8 microM against HIV-2 (CBL20). Those compounds which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology*
  • Cell Line
  • Cell Survival / drug effects
  • Echinodermata / chemistry*
  • HIV-1 / drug effects*
  • HIV-2 / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Porifera / chemistry*
  • Sterols / isolation & purification*
  • Sterols / pharmacology*
  • Structure-Activity Relationship
  • Sulfuric Acid Esters / isolation & purification*
  • Sulfuric Acid Esters / pharmacology*

Substances

  • Antiviral Agents
  • Sterols
  • Sulfuric Acid Esters