Abstract
A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values of 3-13 microM against HIV-1 (RF) and 2-8 microM against HIV-2 (CBL20). Those compounds which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology*
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Cell Line
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Cell Survival / drug effects
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Echinodermata / chemistry*
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HIV-1 / drug effects*
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HIV-2 / drug effects*
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Humans
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Microbial Sensitivity Tests
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Porifera / chemistry*
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Sterols / isolation & purification*
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Sterols / pharmacology*
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Structure-Activity Relationship
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Sulfuric Acid Esters / isolation & purification*
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Sulfuric Acid Esters / pharmacology*
Substances
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Antiviral Agents
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Sterols
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Sulfuric Acid Esters