Dietary trans fatty acids: effects on plasma lipids and lipoproteins of healthy men and women

Am J Clin Nutr. 1994 Apr;59(4):861-8. doi: 10.1093/ajcn/59.4.861.


Effects of cis and trans monounsaturated fatty acids (TFA) and saturated fatty acids were assessed in 29 men and 29 women consuming controlled diets. Subjects ate each diet for 6 wk in a Latin square design. The diets, each with 39-40% of energy as fat were: 1) high oleic (16.7% of energy as oleic acid), 2) moderate TFA (3.8% of energy as TFA), 3) high TFA (6.6% of energy as TFA), 4) and saturated (16.2% of energy as lauric+myristic+palmitic acids). Compared with the oleic diet, LDL cholesterol increased 6.0%, 7.8%, and 9.0% after moderate TFA, high TFA, and saturated diets, respectively. HDL cholesterol was unchanged after moderate TFA, but was slightly lower (2.8%) after high TFA. HDL cholesterol after the saturated diet was 3.5% higher than after the oleic diet. Changes in apolipoproteins B and A-I corresponded with changes in the lipoprotein cholesterols. Thus, compared with oleic acid, dietary TFAs raise LDL cholesterol, but to a slightly lesser degree than do saturates, and high TFA concentrations may result in minor reductions of HDL cholesterol.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Apolipoproteins / analysis
  • Cholesterol / blood
  • Dietary Fats / pharmacology*
  • Fatty Acids / chemistry
  • Fatty Acids / pharmacology*
  • Fatty Acids, Monounsaturated / pharmacology
  • Female
  • Humans
  • Lipids / blood*
  • Lipoproteins / blood*
  • Male
  • Middle Aged
  • Sex Factors
  • Stereoisomerism
  • Triglycerides / blood


  • Apolipoproteins
  • Dietary Fats
  • Fatty Acids
  • Fatty Acids, Monounsaturated
  • Lipids
  • Lipoproteins
  • Triglycerides
  • Cholesterol