Intraarticular injections of hyaluronan in patients with cartilage abnormalities and knee pain. A one-year double-blind, placebo-controlled study

Arthritis Rheum. 1994 Apr;37(4):521-8. doi: 10.1002/art.1780370412.


Objective: To compare the effect of intraarticular injections of hyaluronan and placebo (vehicle, saline) in patients with knee pain on exertion and with joint cartilage abnormalities.

Methods: Fifty-two patients with arthroscopically verified deep cartilage fissures and villus-like flakes in the symptomatic knee were randomly assigned to receive intraarticular injections of 2.5 ml of either hyaluronan or vehicle, weekly for 5 weeks. The effect was evaluated by both primary and secondary parameters of efficacy at 2, 4, 13, 26, and 52 weeks.

Results: At the followup visits, both groups had improvement from baseline; however, there was no difference between the groups in any of the relevant variables at any time point.

Conclusion: The effects of intraarticular hyaluronan do not differ significantly from those of placebo in patients with knee pain and cartilage disease.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cartilage / abnormalities*
  • Double-Blind Method
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / adverse effects
  • Injections, Intra-Articular
  • Knee Joint / abnormalities
  • Middle Aged
  • Pain / drug therapy*
  • Treatment Outcome


  • Hyaluronic Acid