Vascular Endothelial Growth factor/vascular Permeability Factor Is Detectable in the Sera of Tumor-Bearing Mice and Cancer Patients

Biochim Biophys Acta. 1994 Mar 31;1221(2):211-4. doi: 10.1016/0167-4889(94)90016-7.

Abstract

We developed an enzyme-linked immunosorbent assay (ELISA) for vascular endothelial growth factor/vascular permeability factor (VEGF/VPF). The assay revealed that VEGF/VPF levels in the sera of mice were significantly increased from undetectable level by s.c. transplantation with a solid tumor. We also measured VEGF/VPF levels in serum specimens obtained from cancer patients with several types of cancers. VEGF/VPF levels in the sera from cancer patients were significantly higher than those in the sera from the individuals with no sign of cancer.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Endothelial Growth Factors / blood*
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Lymphokines / blood*
  • Mice
  • Neoplasm Transplantation
  • Neoplasms / blood*
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Lymphokines
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors