Histopathologic evaluation of stromal inflammation in Acanthamoeba keratitis

CLAO J. 1994 Jan;20(1):45-8.

Abstract

Ten corneal specimens obtained at the time of penetrating keratoplasty for long-standing refractory Acanthamoeba keratitis were reviewed. Histopathologic findings included epithelial denudation and variable degrees of necrosis, inflammation, and cysts or trophozoites of acanthamoeba in the stroma. No blood vessels were found in the stroma despite the presence of long-standing corneal inflammation. The absence of corneal stromal neovascularization on biomicroscopic and histopathologic examination is a sign of Acanthamoeba keratitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acanthamoeba Keratitis / etiology
  • Acanthamoeba Keratitis / pathology*
  • Acanthamoeba Keratitis / surgery
  • Contact Lenses / adverse effects
  • Corneal Neovascularization / pathology
  • Corneal Stroma / blood supply
  • Corneal Stroma / parasitology
  • Corneal Stroma / pathology*
  • Evaluation Studies as Topic
  • Humans
  • Keratoplasty, Penetrating
  • Retrospective Studies