Anticardiolipin antisera from lupus patients with seizures reduce a GABA receptor-mediated chloride current in snail neurons

Life Sci. 1994;54(15):1119-25. doi: 10.1016/0024-3205(94)00422-6.


The effects of circulating anticardiolipin (ACL) antisera in lupus patients on the LP5 central neuron of snail were studied. Both GABA and glutamate increased a chloride conductance of the LP5 neuron. The ACL antisera decreased the GABA-elicited responses in a concentration dependent manner while it had no effect on glutamate-elicited responses. The ACL antisera affected neither the resting membrane current, nor the membrane conductivity of neuron. Antisera without the activity of anticardiolipin did not decrease the GABA-elicited responses. The seizure incidence of the patients with higher ACL antisera levels is also higher. It is concluded that ACL antisera inhibited the GABA ionophore receptor complex in a snail central neuron.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Anticardiolipin / pharmacology*
  • Chloride Channels / metabolism*
  • Humans
  • Immune Sera
  • Lupus Erythematosus, Systemic / blood
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / immunology*
  • Membrane Potentials
  • Neurons / metabolism*
  • Receptors, GABA / metabolism*
  • Seizures / complications*
  • Snails


  • Antibodies, Anticardiolipin
  • Chloride Channels
  • Immune Sera
  • Receptors, GABA