The potential of computer-assisted instruction in working with individuals who have autism has been a controversial topic for both teachers and parents since its introduction 2 decades ago. In the present study computer-assisted instruction was compared with personal instruction. Four children with autism participated. Although 3 of them showed better motivation and fewer behavior problems in computer-assisted instruction compared to personal instruction, this did not affect their learning-rate. Future directions of computer-assisted instruction research for individuals with autism were discussed.