Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer's disease

Neurosci Lett. 1993 Dec 24;164(1-2):233-5. doi: 10.1016/0304-3940(93)90899-v.

Abstract

Localization of type 2 plasminogen activator inhibitor (PAI-2) was investigated immunohistochemically in postmortem brain tissue of control subjects and patients with Alzheimer's disease (AD). Both the mouse monoclonal and the goat polyclonal antibodies to PAI-2 stained microglia. Reactive microglia were stained more intensely than resting microglia. PAI-2 may regulate the plasminogen activators and plasmin system in lesions of AD. It is suggested that PAI-2 plays a role for cell migration and matrix breakdown as well as for aberrant neurite outgrowth in senile plaques where persistent microglial activation is observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Antibodies / analysis
  • Antibodies, Monoclonal
  • Brain / metabolism*
  • Brain / pathology
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism
  • Humans
  • Immunohistochemistry
  • Leukocytes / metabolism
  • Microglia / metabolism*
  • Middle Aged
  • Plasminogen Activator Inhibitor 2 / biosynthesis*
  • Plasminogen Activator Inhibitor 2 / immunology
  • Up-Regulation / physiology

Substances

  • Antibodies
  • Antibodies, Monoclonal
  • Plasminogen Activator Inhibitor 2