Neuropsychiatric lupus

Rheum Dis Clin North Am. 1994 Feb;20(1):129-58.


Neuropsychiatric disease occurs in up to two thirds of all systemic lupus erythematosus patients. At present, there is no accepted classification for the myriad of neuropsychiatric manifestations that can be divided into diffuse, focal, and seizure presentations. Over the past decade, the pathogenesis of lupus cerebritis has become better understood. Consequently, the approach to the diagnosis and therapy can often be tailored to the suspected underlying etiopathogenesis. Future advancements in therapy will further improve the prognosis of patients with neuropsychiatric lupus erythematosus.

Publication types

  • Review

MeSH terms

  • Brain / pathology
  • Central Nervous System Diseases / etiology
  • Central Nervous System Diseases / immunology
  • Electroencephalography
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / pathology
  • Mental Disorders / etiology
  • Mental Disorders / immunology
  • Nervous System Diseases / etiology*
  • Nervous System Diseases / immunology
  • Peripheral Nervous System Diseases / etiology
  • Peripheral Nervous System Diseases / immunology
  • Prognosis