Quantitative assessment of the blood-aqueous barrier in human eyes with malignant or benign uveal tumors

Am J Ophthalmol. 1994 Apr 15;117(4):521-8. doi: 10.1016/s0002-9394(14)70015-7.


We assessed alterations of the blood-aqueous barrier in 43 eyes with malignant melanoma (31 choroidal and 12 ciliary body), 40 eyes with benign uveal tumors, and 199-age matched normal control eyes. Aqueous flare was quantified with the laser flare-cell meter and correlated with clinical and histopathologic findings. Aqueous flare (photon counts/ms) was significantly higher in melanoma eyes (20.91 +/- 12.40) than in eyes with benign tumors (4.26 +/- 1.55) (P < .0001) and normal control eyes (3.99 +/- 1.14) (P < .0001). In melanoma eyes, clinical and histologic findings associated with significantly increased aqueous flare values were as follows: tumor height, serous retinal detachment, tumor necrosis, lymphocytic tumor infiltration, and tumor hemorrhage. Development and growth of uveal melanomas are accompanied by marked alterations of the blood-aqueous barrier. The noninvasive laser flare-cell meter may give useful additional information about malignant and benign uveal tumors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aqueous Humor / metabolism*
  • Biological Transport, Active
  • Blood / metabolism*
  • Choroid Neoplasms / metabolism
  • Choroid Neoplasms / pathology
  • Ciliary Body / metabolism
  • Ciliary Body / pathology
  • Female
  • Humans
  • Male
  • Melanoma / metabolism*
  • Middle Aged
  • Retinal Detachment / metabolism
  • Retinal Detachment / pathology
  • Uveal Neoplasms / metabolism*
  • Uveal Neoplasms / pathology