Sequences of memory-guided saccades in Parkinson's disease

Ann Neurol. 1994 Apr;35(4):487-90. doi: 10.1002/ana.410350419.


Sequences of ocular saccades were studied in 8 patients with Parkinson's disease, with (i.e., "on") and without (i.e., "off") levodopa treatment. The amplitude of single saccades was decreased and not improved by treatment. The chronology of saccades during sequences was impaired in patients in the "off" state, but significantly improved during the "on" period. These results are compatible with a decreased activation of the supplementary motor area, which can be reversed by levodopa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electrooculography
  • Humans
  • Memory / physiology*
  • Middle Aged
  • Parkinson Disease / physiopathology*
  • Photic Stimulation
  • Reaction Time / physiology
  • Saccades / physiology*