Incidence of ulcerative keratitis in a defined population from 1950 through 1988

Arch Ophthalmol. 1993 Dec;111(12):1665-71. doi: 10.1001/archopht.1993.01090120087027.


Objective: To determine the incidence of ulcerative keratitis and to assess trends in risk factors leading to ulcerative keratitis.

Design: Retrospective incidence cohort study.

Setting: General community.

Patients: Population-based sample of residents of Olmsted County, Minnesota, in the 39-year period between 1950 and 1988.

Main outcome measure: Cases of ulcerative keratitis.

Results: One hundred forty-one cases of ulcerative keratitis were diagnosed among 131 residents (64 men and 67 women) of Olmsted County. The mean annual age-adjusted incidence per 100,000 people was 5.3 (95% confidence interval, 4.4 to 6.2). A 435% increase in the incidence of ulcerative keratitis was observed in Olmsted County residents from the 1950s (2.5 per 100,000 people) to the 1980s (11.0 per 100,000 people) (P = .001). The cases of ulcerative keratitis associated with contact lens wear increased from 0% in the 1950s and 1960s to 32% in the 1970s and 52% in the 1980s.

Conclusion: The incidence of ulcerative keratitis has increased significantly in this community. Contact lens wear was the most important risk factor for the development of ulcerative keratitis during the last decade.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Contact Lenses / adverse effects
  • Corneal Ulcer / epidemiology*
  • Corneal Ulcer / etiology
  • Female
  • Humans
  • Incidence
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Minnesota / epidemiology
  • Population Surveillance
  • Retrospective Studies
  • Risk Factors