The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein

Immunol Today. 1994 Feb;15(2):81-8. doi: 10.1016/0167-5699(94)90138-4.


Following an acute phase stimulus, such as infection or physical injury, many liver-derived plasma proteins are increased in concentration. These provide enhanced protection against invading micro-organisms, limit tissue damage and promote a rapid return to homeostasis. Diana Steel and Alexander Whitehead discuss the gene structure, regulation and possible clinical significance of the most dramatically induced acute phase reactants.

Publication types

  • Review

MeSH terms

  • Acute-Phase Reaction / immunology
  • Animals
  • C-Reactive Protein / biosynthesis
  • C-Reactive Protein / genetics
  • C-Reactive Protein / physiology*
  • Humans
  • Liver / immunology
  • Serum Amyloid A Protein / biosynthesis
  • Serum Amyloid A Protein / genetics
  • Serum Amyloid A Protein / physiology*
  • Serum Amyloid P-Component / biosynthesis
  • Serum Amyloid P-Component / genetics
  • Serum Amyloid P-Component / physiology*


  • Serum Amyloid A Protein
  • Serum Amyloid P-Component
  • C-Reactive Protein