Abstract
Following an acute phase stimulus, such as infection or physical injury, many liver-derived plasma proteins are increased in concentration. These provide enhanced protection against invading micro-organisms, limit tissue damage and promote a rapid return to homeostasis. Diana Steel and Alexander Whitehead discuss the gene structure, regulation and possible clinical significance of the most dramatically induced acute phase reactants.
MeSH terms
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Acute-Phase Reaction / immunology
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Animals
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C-Reactive Protein / biosynthesis
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C-Reactive Protein / genetics
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C-Reactive Protein / physiology*
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Humans
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Liver / immunology
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Serum Amyloid A Protein / biosynthesis
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Serum Amyloid A Protein / genetics
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Serum Amyloid A Protein / physiology*
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Serum Amyloid P-Component / biosynthesis
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Serum Amyloid P-Component / genetics
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Serum Amyloid P-Component / physiology*
Substances
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Serum Amyloid A Protein
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Serum Amyloid P-Component
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C-Reactive Protein