Repeated and persistent infection with Chlamydia and the development of chronic inflammation and disease

Trends Microbiol. 1994 Mar;2(3):94-8. doi: 10.1016/0966-842x(94)90542-8.

Abstract

Chlamydia trachomatis is an important human pathogen that mediates disease processes capable of inflicting permanent damage. Aggressive inflammatory responses to repeated infections, and to a persistent form of this intracellular bacterium, are thought to initiate the pathogenic events that lead to the debilitating sequelae of blinding trachoma and infertility.

Publication types

  • Review

MeSH terms

  • Chlamydia Infections / immunology*
  • Chlamydia Infections / microbiology
  • Chlamydia Infections / pathology*
  • Chlamydia trachomatis / growth & development
  • Chlamydia trachomatis / immunology
  • Chlamydia trachomatis / metabolism*
  • Chronic Disease
  • Female
  • Humans
  • Infertility / etiology
  • Interferon-gamma / immunology
  • Male
  • Recurrence
  • Trachoma / immunology*
  • Trachoma / pathology

Substances

  • Interferon-gamma