Primary fallopian tube adenocarcinoma in situ associated with adjuvant tamoxifen therapy for breast carcinoma

Gynecol Oncol. 1994 Mar;52(3):402-7. doi: 10.1006/gyno.1994.1069.


We report the first case of primary fallopian tube adenocarcinoma in situ in a patient who had received antiestrogen tamoxifen as adjuvant therapy for breast carcinoma. Clinical and in vivo animal model studies, referable to the possible estrogen agonist effect of tamoxifen on the female genital tract, are also reviewed.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / chemically induced*
  • Adenocarcinoma / pathology
  • Breast Neoplasms / drug therapy*
  • Carcinoma in Situ / chemically induced*
  • Carcinoma in Situ / pathology
  • Chemotherapy, Adjuvant
  • Fallopian Tube Neoplasms / chemically induced*
  • Fallopian Tube Neoplasms / pathology
  • Female
  • Humans
  • Middle Aged
  • Neoplasms, Second Primary / chemically induced*
  • Tamoxifen / adverse effects
  • Tamoxifen / therapeutic use*


  • Tamoxifen