Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver

Food Chem Toxicol. 1994 Mar;32(3):279-83. doi: 10.1016/0278-6915(94)90201-1.

Abstract

Male Wistar rats were fed a control diet or the control diet supplemented with 1% (by weight) turmeric for 10 wk. In rats injected with 30 mg Fe2+/kg body weight, lipid peroxidation was 29 and 35% lower in liver homogenates and microsomes, respectively, of turmeric-fed rats than in those of rats fed the control diet. The activities of superoxide dismutase, catalase and glutathione peroxidase were higher (by 19, 19 and 20%, respectively) in liver homogenates of rats fed the turmeric-containing diet in comparison with the controls. These studies indicate that dietary turmeric lowers lipid peroxidation by enhancing the activities of antioxidant enzymes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalase / metabolism
  • Curcuma
  • Curcumin / analogs & derivatives*
  • Curcumin / isolation & purification
  • Curcumin / pharmacology
  • Diet
  • Ferrous Compounds / pharmacology*
  • Glutathione Peroxidase / metabolism
  • Lipid Peroxidation / drug effects*
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species
  • Sesquiterpenes
  • Superoxide Dismutase / metabolism

Substances

  • Ferrous Compounds
  • Plant Extracts
  • Reactive Oxygen Species
  • Sesquiterpenes
  • ferrous sulfate
  • alpha-curcumene
  • turmeric extract
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Curcumin