Concurrent invasive thymoma and T-cell lymphoblastic leukemia and lymphoma. A case report with necropsy findings and literature review of thymoma and associated hematologic neoplasm

Am J Clin Pathol. 1994 Apr;101(4):432-7. doi: 10.1093/ajcp/101.4.432.


Thymoma is associated with benign and neoplastic diseases. The authors report the concurrence of invasive thymoma and T-lymphoblastic leukemia/lymphoma in a 95-year-old man. The hematologic malignancy was suspected terminally, whereas the thymoma was discovered at necropsy. The lymphoblastic leukemia/lymphoma had a clonally rearranged T-cell receptor beta-chain gene and a mature thymocyte immunophenotype. No retroviral gene sequences (human immunodeficiency virus 1 and 2, and human T-cell leukemia virus 1 and 2) were identified by polymerase chain reaction and hybridization analysis. The association of thymoma with hematologic neoplasm is reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abdominal Neoplasms / immunology
  • Abdominal Neoplasms / pathology*
  • Aged
  • Aged, 80 and over
  • Antigens, CD / analysis
  • Humans
  • Leukemia, Lymphoid / immunology
  • Leukemia, Lymphoid / pathology*
  • Leukemia-Lymphoma, Adult T-Cell / immunology
  • Leukemia-Lymphoma, Adult T-Cell / pathology*
  • Male
  • Mediastinal Neoplasms / immunology
  • Mediastinal Neoplasms / pathology*
  • Neoplasms, Multiple Primary / immunology
  • Neoplasms, Multiple Primary / pathology*
  • Thymoma / immunology
  • Thymoma / pathology*


  • Antigens, CD