Southwestern internal medicine conference: sarcoidosis: immunology and clinical management

Am J Med Sci. 1994 Mar;307(3):233-45. doi: 10.1097/00000441-199403000-00012.


Sarcoidosis is a chronic inflammatory disease characterized by the presence of noncaseating granulomas in the lung and other organs. Current evidence suggests that this response is driven by a foreign antigen whose identity remains unclear. In this article, the nature of the cellular immune response is explored and the value of local markers of inflammation in predicting clinical course is examined.

Publication types

  • Review

MeSH terms

  • Antigens / analysis
  • Humans
  • Macrophages, Alveolar / physiology
  • Radiography, Thoracic
  • Receptors, Interleukin-2 / analysis
  • Sarcoidosis / diagnosis
  • Sarcoidosis / immunology*
  • Sarcoidosis / therapy
  • Sarcoidosis, Pulmonary / immunology*
  • Sarcoidosis, Pulmonary / therapy
  • T-Lymphocytes / physiology


  • Antigens
  • Receptors, Interleukin-2