Duplication and deletion of chromosome band 2(p21p22) resulting from a familial interstitial insertion (2;11)(p21;p15)

Am J Med Genet. 1994 Feb 15;49(4):422-7. doi: 10.1002/ajmg.1320490414.


Routine amniocentesis for advanced maternal age led to the prenatal diagnosis of a fetus with a karyotype of a 46,XX,del(2)(p21p22). At delivery the baby had holoprosencephaly as the major clinical finding, which has been associated with a deletion of band 2p21 in several other case reports. Chromosome studies of the parents showed a normal 46,XY karyotype in the father, and a balanced interstitial insertion 46,XX dir ins (11;2)(p15.1;p21p22) in the mother. Subsequent chromosome studies of other relatives documented a 23-year-old half-brother of the proposita with a partial trisomy for the segment deleted in the proposita. The half-brother showed the derivative chromosome 11 from the mother, resulting in a 46,XY,der(11)dup(2)(p21p22) karyotype. Major clinical findings include short stature, mild developmental delay, and behavior abnormalities. A half-sister of the proposita is also a balanced carrier of the dir ins (11;2) (p15.1;p21p22.2). The association of the deletion chromosome band 2p21 and the clinical finding of holoprosencephaly is further supported by the findings in this family.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chromosome Aberrations
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 11*
  • Chromosomes, Human, Pair 2*
  • Female
  • Holoprosencephaly / genetics
  • Humans
  • Infant, Newborn
  • Karyotyping
  • Male
  • Multigene Family*
  • Pedigree