Osseous substance formation induced in porous calcium phosphate ceramics in soft tissues

Biomaterials. 1994 Jan;15(1):31-4. doi: 10.1016/0142-9612(94)90193-7.

Abstract

Porous calcium phosphate ceramics prepared according to the methods of laboratories in Leiden were implanted subcutaneously in rats for 3, 6 and 12 w. No bone formation could be observed. Porous calcium phosphate ceramics prepared according to the methods of laboratories in Sichuan were implanted subcutaneously/intramuscularly in dogs for 1, 3, 5 and 7 months. In particular, ceramics containing alpha-tricalcium phosphate evoked bone formation in the pores of the ceramics. The amount of bone was similar at the different time periods.

MeSH terms

  • Animals
  • Bone Development / drug effects*
  • Bone and Bones / pathology
  • Calcium Phosphates / pharmacology*
  • Ceramics*
  • Dogs
  • Prostheses and Implants*
  • Rats

Substances

  • Calcium Phosphates