Host Cell Proteases Controlling Virus Pathogenicity

Trends Microbiol. 1994 Feb;2(2):39-43. doi: 10.1016/0966-842x(94)90123-6.

Abstract

The majority of viral glycoproteins that undergo post-translational proteolysis are cleaved by ubiquitous intracellular proteases; however, a minority are cleaved by secreted proteases available only in a few host systems. The interplay of viral glycoproteins and cellular proteases may have a pivotal role in the spread of infection, host range and pathogenicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites / genetics
  • Consensus Sequence
  • Endopeptidases / metabolism*
  • Glycoproteins / genetics
  • Glycoproteins / metabolism
  • Humans
  • Molecular Sequence Data
  • Protein Processing, Post-Translational
  • Viral Proteins / genetics
  • Viral Proteins / metabolism
  • Virus Diseases / metabolism
  • Virus Diseases / microbiology
  • Viruses / genetics
  • Viruses / metabolism
  • Viruses / pathogenicity*

Substances

  • Glycoproteins
  • Viral Proteins
  • Endopeptidases